Nuclear phosphoinositide regulation of chromatin
نویسندگان
چکیده
منابع مشابه
Roles of Chromatin insulators in gene regulation and diseases
With advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. Long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. Chromatin insulators are key determinants of proper gene regulation and precise organization of c...
متن کاملThe PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor
Phosphoinositides (PtdInsPs) play critical roles in cytoplasmic signal transduction pathways. However, their functions in the nucleus are unclear, as specific nuclear receptors for PtdInsPs have not been identified. Here, we show that ING2, a candidate tumor suppressor protein, is a nuclear PtdInsP receptor. ING2 contains a plant homeodomain (PHD) finger, a motif common to many chromatin-regula...
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Transcription regulation by bile acids is far more complicated than it appeared at first when several groups began their investigations in the early '90. It has become clear now that bile acids regulate the transcription of genes involved in bile acid synthesis, transport and other metabolic pathways via multiple mechanisms that involve transcription factors, nuclear receptors, coregulators, ch...
متن کاملroles of chromatin insulators in gene regulation and diseases
with advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. chromatin insulators are key determinants of proper gene regulation and precise organization of c...
متن کاملRegulation of phosphoinositide-specific phospholipase C.
The receptors involved in the regulation of phospholipase C by hormones, neurotransmitters and other ligands have seven transmembrane-spanning hydrophobic regions (seven-helix motif) and no known enzymatic activity. Furthermore these receptors can be isolated as complexes with guanine nucleotide binding (G) proteins. Guanine nucleotides affect the binding of hormones that stimulate phospholipas...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2017
ISSN: 0021-9541
DOI: 10.1002/jcp.25886